Donnerstag, 25.09.2014

10:00 - 10:45 Uhr

Audimax HS XII

Vorsitz: Haendeler, Judith (Düsseldorf)

Skin as an Index Organ of Extrinsic Ageing in Humans

Friedrich Boege
Friedrich Boege

Ageing has two principal determinants, the intrinsic disposition delineating what is possible, and extrinsic factors determining how the pre-set frame is individually exploited. Extrinsic ageing affects health span of brain, hear, vasculature, kidney and skin, which is the human organ most readily accessible to inspection and minimally invasive diagnostics. Many processes of extrinsic skin ageing converge on the dermis, a post-mitotic skin compartment mainly consisting of extracellular matrix and fi broblasts. Dermal fi broblasts are long-lived cells constantly undergoing ageing-associated damage accumulation and (mal-) adaptation, and thus may constitute a powerful indicator system for extrinsic human ageing. Dermal fi broblast ageing combines a subset of ubiquitous hallmarks of ageing with features that are specifi c for extrinsic ageing processes in this particular cell type. Moreover, ageing of human dermal fi broblasts in situ recapitulates some but not all features associated with replicative or stressinduced fi broblast senescence in vitro. Finally, features of extrinsic ageing observed in dermal fi broblasts are notably different from those observed in aged animal models or human skin biopsies. These observations suggest that skin and particularly dermal fi broblast may be a suitable indicator system for extrinsic ageing in humans, but further efforts are needed to distinguish those features providing valid biomarkers for that purpose.

Univ.-Prof. Dr. med. Friedrich Boege ist Direktor des Zentralinstituts für Klinische Chemie und Laboratoriumsdiagnostik an der Heinrich Heine Universität Düsseldorf